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Voltage-gated Ca2+ channels are unaffected in Prnp0/0 neurons. A, Ca2+ current amplitude and kinetics were unaffected in Prnp0/0 neurons in response to a 200 ms step depolarization. The Ca2+ changes, as monitored by 100 μm Fura-2, were significantly smaller in Prnp0/0 neurons (bottom, gray trace) than in Prnp +/+ neurons (for statistics, see Results). B, Ca2+ current-voltage relationship is not altered in Prnp0/0 neurons (•, Prnp +/+; ○, Prnp0/0).
