Table 1.

Significant changes (increase of cerebral gray matter) during the time of skilled performance (scan 2) compared with time point one

Region	Brodmann's areas	Talairach coordinates (x, y, z)	Z score of peak activation
Main effects analysis (n = 25)
R hMT/V5	18	25, −92, −1	4.03*
L Hippocampus		−18, −11, −21	4.79
Cingulate cortex	24	−3, 40, 6	4.07
L Superior frontal gyrus	10	−17, 61, −3	3.54
R Gyrus precentralis	4	12, −21, 74	4.72
Interaction analysis (n = 50)
hMT/V5 R	18	24, −91, 3	3.21
L Hippocampus		−18, −11, −21	4.45
L Nucleus accumbens		−19, 3, −14	4.79
R Nucleus accumbens		19, 5, −13	4.01

This pattern reversed when study participants were examined at time point 3 (after the weeks without practicing). The changes are tabulated in terms of the brain region and the corresponding Brodmann's area. The x, y, and z coordinates are according to the Montreal Neurological Institute and International Consortium for Brain Mapping (http://www.loni.ucla.edu/ICBM/). Each location is the peak within a cluster (defined as the voxel with the highest Z-score). L, Left; r, right.

*Corrected for multiple comparisons (SVC).