Figure 3.

NE increases neuronal excitability in IL pyramidal neurons via β-receptors and PKA. A, Photomicrograph of IL pyramidal cell filled with biocytin. Scale bar, 100 mm. B, Individual traces from an IL pyramidal cell showing the number of spikes evoked by a depolarizing current pulse before and after bath-applied NE. C, NE-induced increases in spikes were prevented by previous treatment with 100 μm propranolol or 500 μm intracellular Rp-cAMPS. D, Example traces from a single cell showing that NE converted the sAHP to an afterdepolarizing potential. E, Group data showing that this effect of NE was prevented by previous application of propranolol or Rp-cAMPS. *p < 0.05 compared with control. Error bars indicate SEM.