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. 2008 Jan 9;28(2):425–433. doi: 10.1523/JNEUROSCI.3602-07.2008

Figure 3.

Figure 3.

Behavioral phenotypes of CamDAT mice. A, DOX treatment was required for the survival of CamDAT mice. B, In the open field, locomotor activity of CamDAT mice was normal 1 week after DOX withdrawal. However, their locomotor activity sharply declined in the second week of DOX withdrawal (n = 4 per group, repeated-measures ANOVA, p < 0.001). C, Progressive body weight loss in CamDAT mice after DOX withdrawal (n = 6, repeated-measures ANOVA, p < 0.001 for group × week interaction). D, Four weeks after DOX withdrawal, CamDAT mice in their home cages consumed very little regular rodent chow (n = 5 per group, individually housed, unpaired t test, p < 0.001). E, Two weeks after DOX withdrawal, when provided with easily accessible chocolate flavored pellets (20 mg each) on the cage floor, CamDAT mice ate more than TetDAT mice (n = 6 per group, repeated-measures ANOVA, p < 0.001 for group × week interaction).