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Motor dysfunction in CamDAT mice is dopamine supply dependent. DOX treatment was removed 1 month after unilateral 6-OHDA lesion, and stepping of the forelimb controlled by the intact side worsened progressively, dropping from 100 to 15% of baseline level during 4 weeks DOX withdrawal, whereas stepping of the forelimb controlled by the lesion side improved from 16 to 50% of baseline level (n = 5 per group, repeated-measures ANOVA, p < 0.001 for side × week interaction).
