Table 3.
BOLD responses to experimental stimuli
| IBS |
Control |
IBS > control |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cluster |
Voxel |
Cluster |
Voxel |
Cluster |
Voxel |
|||||||||||||||
| k | p(cor) | ROI0.01 | t | p(cor) | x, y, z | k | p(cor) | ROI0.01 | t | p(cor) | x, y, z | k | p(cor) | ROI0.01 | t | p(cor) | x, y, z | |||
| 45 mmHg increase | ||||||||||||||||||||
| Anterior insula | L | 620 | 0.00* | 69% | 7.61 | 0.00* | −36, 26, −8 | 264 | 0.001 | 29% | 5.63 | 0.002 | −40, 8, 6 | |||||||
| R | 540 | 0.00* | 51% | 6.16 | 0.001 | 38, 24, −12 | 279 | 0.001 | 29% | 4.78 | 0.02 | 42, 4, 2 | ||||||||
| Posterior insula | L | 371 | 0.00* | 32% | 6.78 | 0.00* | −48, 2, 2 | 129 | 0.02 | 9% | 5.65 | 0.004 | −40, 6, 6 | |||||||
| R | 320 | 0.00* | 30% | 6.05 | 0.001 | 48, 4, 0 | 37 | 0.14 | 4% | 5.41 | 0.004 | 42, 4, 4 | ||||||||
| Dorsal brainstem | L | 130 | 0.005 | 38% | 5.71 | 0.001 | −6, −42, −24 | 10 | 0.17 | 6% | 3.78 | 0.04 | −6, −42, −24 | |||||||
| R | 150 | 0.003 | 44% | 6.04 | 0.00* | 8, −30, −20 | ||||||||||||||
| ACC dorsal | L | 234 | 0.001 | 43% | 5.35 | 0.003 | −8, 4, 42 | 51 | 0.05 | 10% | 3.18 | 0.17 | −8, 12, 42 | |||||||
| R | 161 | 0.003 | 45% | 5.15 | 0.003 | 0, 16, 38 | ||||||||||||||
| 45 mmHg decrease | ||||||||||||||||||||
| ACC supragenual | L | |||||||||||||||||||
| R | 29 | 0.14 | 3% | 3.74 | 0.09 | 6, 34, 2 | ||||||||||||||
| ACC infragenual | L | 142 | 0.004 | 39% | 3.92 | 0.04 | −6, 32, −6 | 116 | 0.008 | 32% | 3.74 | 0.05 | −6, 44, −4 | |||||||
| R | 12 | 0.16 | 16% | 3.77 | 0.04 | 10, 52, −4 | ||||||||||||||
| 25 mmHg increase | ||||||||||||||||||||
| Anterior insula | L | 545 | 0.00* | 61% | 6.14 | 0.001 | −38, 20, −2 | 245 | 0.002 | 28% | 5.05 | 0.007 | −32, 28, −6 | |||||||
| R | 526 | 0.00* | 50% | 5.81 | 0.002 | 48, 10, −2 | 328 | 0.00* | 31% | 5.99 | 0.001 | 36, 22, 4 | ||||||||
| Posterior insula | L | 211 | 0.004 | 15% | 5.64 | 0.003 | −48, 2, 0 | |||||||||||||
| R | 41 | 0.13 | 6% | 4.84 | 0.01 | 46, 12, −6 | 28 | 0.19 | 4% | 4.04 | 0.06 | 40, −14, 4 | ||||||||
| Dorsal brainstem | L | 18 | 0.12 | 7% | 3.65 | 0.05 | −4, −28, −14 | |||||||||||||
| R | 53 | 0.04 | 15% | 4.34 | 0.01 | 6, −30, −20 | ||||||||||||||
| ACC dorsal | L | 56 | 0.05 | 14% | 3.87 | 0.05 | −6, 18, 42 | |||||||||||||
| R | 25 | 0.11 | 14% | 4.12 | 0.02 | 6, 8, 28 | 8 | 0.21 | 2% | 3.56 | 0.07 | 6, 10, 28 | ||||||||
| 25 mmHg decrease | ||||||||||||||||||||
| ACC infragenual | L | 42 | 0.06 | 12% | 3.23 | 0.12 | −8, 44, −12 | 128 | 0.008 | 35% | 3.66 | 0.05 | −12, 36, −10 | |||||||
| R | 53 | 0.04 | 15% | 5.34 | 0.002 | 12, 50, −6 | 26 | 0.09 | 10% | 2.97 | 0.16 | 6, 52, −4 | ||||||||
| Amygdala | L | 72 | 0.02 | 30% | 4.39 | 0.01 | −20, −8, −24 | 6 | 0.19 | 3% | 3.43 | 0.07 | −28, −12, −14 | |||||||
| R | 52 | 0.04 | 21% | 5.37 | 0.001 | 20, −6, −22 | 31 | 0.07 | 13% | 3.75 | 0.04 | 20, −6, −22 | ||||||||
| 5 mmHg increase | ||||||||||||||||||||
| Anterior insula | L | 201 | 0.004 | 23% | 5.04 | 0.007 | −34, 22, 4 | |||||||||||||
| R | 252 | 0.002 | 24% | 4.39 | 0.03 | 28, 26, −2 | ||||||||||||||
| ACC dorsal | L | 14 | 0.18 | 5% | 3.71 | 0.06 | −14, 0, 38 | |||||||||||||
| R | ||||||||||||||||||||
| 5 mmHg decrease | ||||||||||||||||||||
| Amygdala | L | 20 | 0.10 | 8% | 4.46 | 0.009 | −26, −4, −24 | |||||||||||||
| R | 5 | 0.19 | 2% | 3.22 | 0.09 | 22, −6, −22 | ||||||||||||||
| Cue decrease | ||||||||||||||||||||
| Anterior insula | L | 3 | 0.46 | 11% | 4.74 | 0.02 | −28, 32, −2 | |||||||||||||
| R | 285 | 0.00* | 27% | 4.93 | 0.01 | 36, 8, 2 | ||||||||||||||
| Posterior insula | L | 218 | 0.002 | 22% | 4.96 | 0.02 | −46, 0, 8 | |||||||||||||
| R | 306 | 0.00* | 28% | 5.11 | 0.009 | 42, −14, −6 | 94 | 0.02 | 9% | 4.33 | 0.04 | 40, −10, 6 | ||||||||
| Dorsal brainstem | L | 198 | 0.001 | 58% | 4.49 | 0.01 | −6, −26, −12 | 85 | 0.01 | 25% | 4.01 | 0.03 | −4, −26, −12 | |||||||
| R | 118 | 0.005 | 34% | 4.56 | 0.01 | 10, −24, −6 | 22 | 0.10 | 9% | 3.76 | 0.05 | 4, −30, −24 | ||||||||
| ACC dorsal | L | |||||||||||||||||||
| R | 31 | 0.08 | 7% | 3.79 | 0.05 | 4, 14, 42 | ||||||||||||||
| ACC supragenual | L | 68 | 0.04 | 8% | 3.87 | 0.08 | −10, 32, 22 | |||||||||||||
| R | 59 | 0.05 | 7% | 3.62 | 0.13 | 2, 30, 24 | ||||||||||||||
| Amygdala | L | 98 | 0.008 | 40% | 4.24 | 0.02 | −22, −4, −24 | |||||||||||||
| R | 9 | 0.16 | 4% | 3.89 | 0.09 | 26, 2, −26 | ||||||||||||||
For each region where peak voxel height or the spatial extent volume-corrected p < 0.1 of that cluster, the cluster size (number of voxels) is labeled k, followed by the volume-corrected probability associated with finding a cluster this large or larger [p(cor)]. Because the peak cluster is not always within the largest cluster, the two cluster columns are followed by an additional measure of spatial extent, the total percentage of ROI voxels where p < 0.01 (uncorrected), although there is no accepted statistical test associated with this measure. The three voxel columns present the peak voxel t-score, the volume corrected probability of finding a t-score this large or larger [p(cor)], and location in MNI space. The x, y, z coordinates represent approximate millimeter distances from the anterior commissure (voxel 0 0 0), with positive values to the right, anterior, and superior directions, respectively. Formal group comparisons are presented in the rightmost columns. All these results represent larger BOLD signal in the IBS-C group. It should be noted that this represents a bigger change from the resting baseline state in the control group in ROIs where the primary response to a stimulus was a BOLD decrease. ROI0.01, Proportion of the region of interest where p < 0.01 (uncorrected). *p < 0.0005.