Figure 4.

Reduction of open-field activity after chronic treatment of mice with fluoxetine. A, Effects of orally applied fluoxetine on nocturnal home cage activity (n = 8 each). B, Patterns of home cage activity during 24 h before and during the fluoxetine treatment. The light and dark periods are indicated by open and filled bars on the top, respectively. C, Reduction of open-field activity in the fluoxetine-treated mice (n = 8 each). D, Lack of significant effects of fluoxetine on motor skills of mice. The latency to fall from the rod in the accelerating rotarod test is shown. Error bars indicate SEM.