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. 2008 Jun 11;28(24):6239–6249. doi: 10.1523/JNEUROSCI.4956-07.2008

Figure 7.

Figure 7.

Age-dependent onset of cognitive impairment in DAL mice. Performance on the MWM test. A, At the age of 6 months, time to reach a hidden platform (latency) was similar in the DAL101 and C57BL/6 mice. However, the 12- and 18-month-old DAL101 mice showed profound impairment compared with C57BL/6 mice. B, Probe test performed 1 h after the hidden platform acquisition period. At the age of 6 months, time spent in the target quadrant was similar in the DAL101 (filled bars) and C57BL/6 (open bars) mice. However, the 12- and 18-month-old DAL101 mice spent a shorter time searching in the target quadrant than C57BL/6 mice (mean ± SD). *p < 0.05. C, Time to reach visible platform locations. Filled bars, DAL101; open bars, C57BL/6. D, Swimming speed during probe trial.