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TRP channel-mediated CBD-evoked CGRP release. A–C, CGRP release in response to 100 nm CAP (A), 30 μm CBD (B), or 30 μm MO (C), in the presence of 10 μm CPZ, no calcium, 10 μm RR, 10 μm SR141716A, 10 μm SR144528, or buffer (BL). D, CGRP release in response to a second exposure of the same or a different agonist (e.g., MO/CBD indicates first treatment with MO followed by CBD). *p < 0.05; **p < 0.01.
