Figure 3.

R/hCRF facilitated a DA-induced depression of putative BLA–mPFC EPSCs in the presence of raclopride, a D₂-like antagonist, in saline-treated animals. A, Bar graph depicts reversible and significant DA-mediated depression of EPSCs in the presence of 10 μm raclopride. Raclopride, itself, did not have a significant effect on EPSC amplitude. DA (10 μm) combined with r/hCRF (50 nm) produced a greater depressive effect on EPSCs, indicating that r/hCRF (50 nm) facilitated DA-induced EPSC depression. B, Top, Representative averaged traces of EPSCs taken at different time points, indicated by numbers. Bottom, Input conductance plotted as a function of time.