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. 2008 Jan 9;28(2):465–472. doi: 10.1523/JNEUROSCI.4778-07.2008

Figure 3.

Figure 3.

A hypomorphic mutation of the Eip55E gene enhances α-synuclein-induced DA neuron loss. A, Eip55EKG02526 homozygotes do not display detectable loss of DA neurons in the PPL1 cluster relative to flies bearing two copies of the TH-GAL4 driver. However, the DA neuron loss in the PPL1 cluster that is observed in 20-d-old flies bearing two copies of the UAS-Syn and TH-GAL4 transgenes is further reduced in flies homozygous for the Eip55EKG02526 mutation (**p < 0.005). However, the neuronal loss seen in CG4365Δ homozygotes bearing two copies of the UAS-Syn and TH-GAL4 transgenes is indistinguishable from that of WT flies bearing two copies of the UAS-Syn and TH-GAL4 transgenes. B, C, Representative images of PPL1 neurons from 20-d-old Eip55EKG02526 homozygotes (B) and 20-d-old Eip55EKG02526 homozygotes bearing two copies of the UAS-Syn and TH-GAL4 transgenes (C).