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Neurodegeneration of the substantia nigra in Psmc1 fl/fl;TH Cre mice. A–C, Immunohistochemistry using antibodies to TH (A), ubiquitin (B), and GFAP (C) (10×). A, TH immunostaining identifies nigral neurons in control and Psmc1 fl/fl;TH Cre (mutant) horizontal brain sections at 3 weeks of age. B, C, Increased ubiquitin (B) and astrocytic gliosis (C) in the substantia nigra of the mutant brain.
