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. 2008 Mar 26;28(13):3404–3414. doi: 10.1523/JNEUROSCI.0157-08.2008

Figure 2.

Figure 2.

SCI induces activation and processing of caspase-1 and increases levels of ASC and caspase-11 but not NALP1. A–D, Representative immunoblot analysis of caspase-1 (A), caspase-11 (B), ASC (C), and NALP1 (D) in spinal cord lysates of sham (Sh) and traumatized rat cords at indicated times after injury. C shows that anti-ASC reacts specifically with ASC (26 kDa) and nonspecifically with proteins of ∼49 and 55 kDa (arrows, left). β-Tubulin was used as internal standard and control for protein loading. Data are presented as mean ± SEM. *p < 0.05, #p < 0.10 compared with sham. n = 5 per group.