Figure 1.
Development of the STDP model. A, Electrophysiological compartment model. B, Postsynaptic signaling cascades model, which includes Ca2+ influx and removal and biochemical interactions. C, AMPAR trafficking model. The arrows and lines with a black circle indicate stimulatory and inhibitory interactions, respectively. Molecules required for LTP and LTD are indicated by red and blue, respectively. The detailed description of the models is provided as supplemental information (available at http://www.kurodalab.org/info/STDP/Urakubo2008SI.pdf).