Figure 7.

Burst-dependent synaptic plasticity. A, B, Changes of synaptic strength by presynaptic bursts with a single postsynaptic spike. The presynaptic spikes (with the indicated numbers) with 100 Hz after (A) or before (B) a postsynaptic spike was given at 1 Hz for 100 times. The interval between the postspiking and the nearest prespiking was 6 ms. Closed circles indicate synaptic conductance in the allosteric model (average of three trials; SEM <0.21%), and open circles indicate the correspondence in experiment (mean ± SEM) (Froemke et al., 2006) (A–D). C, Changes of synaptic strength by postsynaptic bursts with a single presynaptic spike. The postspikes (with the indicated numbers) with 100 Hz together with a prespike were given at 1 Hz for 100 times, and synaptic conductance was plotted. The interval between the prespiking and the first postspiking was 6 ms. D, Burst frequency-dependent synaptic plasticity. Five pairings of prespiking → postspiking (circles) and postspiking → prespiking (squares) with the indicated frequencies were given at 1 Hz for 100 times, and synaptic conductance was plotted (average of three trials; SEM <0.26%).