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. 2008 Mar 26;28(13):3310–3323. doi: 10.1523/JNEUROSCI.0303-08.2008

Figure 8.

Figure 8.

Requirement of postsynaptic NMDARs for the induction of LTD in STDP. Intracellular MK-801 (1 mm) prevented pairing-induced LTD. Examples of data from two simultaneously recorded neurons in the same slice are shown. Top, Recording with MK-801 in the internal solution. Bottom, Recording from a nearby neuron (∼25 μm away). At the time indicated by the arrow, postspike → prespike pairing [Tpost − Tpre = −9.6 ms (top), −10.3 ms (bottom)] was repeated. Red and blue lines indicate increase (11.8%; p > 0.2) and decrease (−44.8%; p < 10−10) in synaptic strength. EPSP slope is shown in the top panel, and input resistance (Ri) is shown in the bottom panel.