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Homer3 phosphorylation modulated the glutamate-induced Ca2+ release in heterologous cells. A–C, HeLa cells expressed with mGluR1α alone or with wild-type Homer3 (WT), S120A/S159A/S176A mutant (AAA), or S120D/S159D/S176D mutant (DDD) and loaded with fura-2. [Ca2+]i signaling induced by glutamate was examined on sensitivity at 1 μm glutamate (A) and on the [Ca2+]i signaling pattern induced at 10 μm glutamate (B, C).
