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. 2008 Mar 12;28(11):2933–2940. doi: 10.1523/JNEUROSCI.5723-07.2008

Figure 2.

Figure 2.

Effect of 5-HT2B receptor inhibition on MDMA-induced 5-HT release as measured by in vivo microdialysis. a, Effect of MDMA (10 mg/kg; triangles) or saline injection (squares) on 5-HT concentrations in dialysates from NAcc of WT mice. b, c, Effect of RS127445 (5-HT2B receptor antagonist; b) or 5-HT2B receptor genetic ablation (c) on MDMA-induced 5-HT release in NAcc. d, Effect of saline (squares) or MDMA (triangles) in WT mice on 5-HT level in the VTA. e, f, Effect of MDMA in RS127445-treated mice (diamonds; e) or in 5-HT2B−/− mice (open circles; f) on 5-HT level in the VTA. MDMA or saline solutions were injected 35 min after testing began (arrow). Data (means ± SEM; n = 5 per group) were analyzed using two-way ANOVA: effect of MDMA on 5-HT level in the NAcc WT mice, F(1,144) = 6822.46; p < 0.0001; effect of MDMA on 5-HT level in 5-HT2B−/− NAcc or VTA mice, ns; effect of MDMA on 5-HT level in RS127445-treated mice NAcc or VTA mice, ns; effect of MDMA on 5-HT level in the VTA, F(18,162) = 110.29; p < 0.0001. A Bonferroni posttest was also applied on each graph. ***p < 0.001; ns: nonsignificant.