Figure 3.
Effect of 5-HT2B receptor inhibition on MDMA-induced DA release as measured by in vivo microdialysis in NAcc. a, Effect of MDMA (10 mg/kg; open squares) or saline injection (filled squares) on DA concentrations in dialysates from NAcc of WT mice. b, Effect of RS127445 (0.5 mg/kg; diamonds) on MDMA-induced DA release in NAcc. c, Effect of 5-HT2B receptor genetic ablation (open circles) on MDMA-induced DA release in NAcc. MDMA or saline solutions were injected 35 min after testing began (arrow). Data (means ± SEM; n = 5 per group) were analyzed using two-way ANOVA: effect of MDMA on DA level in the NAcc WT mice, F(1,144) = 9162.79; p < 0.0001; effect of MDMA on DA level in RS127445-treated mice, ns; effect of MDMA on DA level in NAcc 5-HT2B−/− mice, ns. A Bonferroni posttest was also applied on each graph. *p < 0.05; **p < 0.01; ***p < 0.001; ns, nonsignificant.