Table 1.
Maturation of intrinsic membrane properties and spontaneous input: development
| Cell type | Parameter | Rank correlation with postnatal day or dpi |
Group means ± SEM (n) |
||||
|---|---|---|---|---|---|---|---|
| r | p | n | Pw1 | Pw4 | Adult | ||
| ETC | Rm | −0.21 | 0.11 | 60 | 714 ± 78 MΩ (26) | 562 ± 53 MΩ (11) | |
| Cm | −0.20 | 0.12 | 59 | 29.1 ± 1.7 pF (26) | 21.8 ± 2.0 pF (10)* | ||
| Peak Na+ current | 0.33 | 0.01 | 59 | 96 ± 12 pA/pF (26) | 206 ± 38 pA/pF (10)* | ||
| sEPSC frequency | 0.20 | 0.14 | 57 | 0.81 ± 0.21 Hz (23) | 2.03 ± 0.80 Hz (11) | ||
| sEPSC amplitude | −0.32 | 0.02 | 53 | 17.4 ± 1.5 pA (22) | 12.8 ± 0.9 pA (10)* | ||
| sIPSC frequency | 0.57 | <0.0001 | 52 | 0.08 ± 0.04 Hz (19) | 0.86 ± 0.34 Hz (11)** | ||
| sIPSC amplitude | 0.38 | 0.03 | 33 | 10.0 ± 1.0 pA (6) | 13.6 ± 1.6 pA (9) | ||
| PGC | Rm | −0.27 | <0.0001 | 254 | 2526 ± 108 MΩ (106) | 2006 ± 107 MΩ (72)** | 1927 ± 169 MΩ (41)**, ns |
| Cm | −0.04 | 0.50 | 223 | 12.3 ± 0.4 pF (94) | 12.0 ± 0.6 pF (66) | 11.0 ± 10.6 pF (36) | |
| Peak Na+ current | 0.44 | <0.0001 | 218 | 85 ± 10 pA/pF (91) | 157 ± 14 pA/pF (64)*** | 188 ± 21 pA/pF (36)***, ns | |
| sEPSC frequency | 0.30 | <0.0001 | 220 | 0.14 ± 0.03 Hz (89) | 1.40 ± 0.32 Hz (59)*** | 1.11 ± 0.37 Hz (38) ns, * | |
| sEPSC amplitude | −0.35 | <0.0001 | 163 | 24.5 ± 2.0 pA (58) | 17.8 ± 1.0 pA (51) ns | 13.8 ± 1.0 pA (26)***, * | |
| sIPSC frequency | 0.51 | <0.0001 | 136 | 0.03 ± 0.02 Hz (40) | 0.36 ± 0.12 Hz (34)*** | 0.87 ± 0.34 Hz (30)***, ns | |
| sIPSC amplitude | 0.20 | 0.08 | 81 | 18.6 ± 5.1 pA (9) | 14.4 ± 1.3 pA (26) | 18.4 ± 2.3 pA (26) | |
Values in bold come from significant correlations or group comparisons (p < 0.05). For two-sample group comparisons (t test or Mann–Whitney test, depending on sample normality), the significance level is displayed at the end of the Pw4 column. For three-sample group comparisons, bold values indicate a significant overall difference between groups in a parametric or nonparametric ANOVA (depending on sample normality). The results of post hoc comparisons between groups are then shown at the end of the Pw4 and Adult columns. The Pw4 column contains the result of a comparison between the Pw1 and Pw4 columns, whereas the Adult column shows the results of comparisons between the Pw1 and Adult columns and between the Pw4 and Adult columns, in that order. *p < 0.05; **p < 0.01; ***p < 0.001; ns, nonsignificant.