Figure 3.

Depressed subjects have significantly more raft-associated Gsα in the cerebellum and prefrontal cortex compared with control subjects. Graphic representation of the normalized densitometric ratios of TX-100-soluble and TX-100-resistant Gsα (TX-100/TX-114). A, Data were acquired from gels and autoradiographs on cerebellum samples. An unpaired t test was performed and the means were found to be significantly different, p < 0.02 (n = 14 for control and n = 13 for suicide subjects). B, Data were acquired from gels and autoradiographs from prefrontal cortex samples, and the average of those ratios is presented. An unpaired t test was performed, and the means were found to be significantly different, p < 0.05 (n = 14 for control and n = 15 for suicide subjects).