Figure 6.

Conversion of synaptic plasticity direction is not attributable to partial inhibition of NMDAR function after recovery from MK-801 block. A, The graph displays progressive recovery of evoked NMDAR-mediated EPSCs from MK-801 block recorded in perforated patch mode. The representative averaged traces from indicated times are presented above the graph. B, AP-5 at a concentration of 5–8 μm, which could reduce NMDAR-mediated EPSCs to a level similar to that observed after recovery from MK-801 block, did not induce conversion of LTP to LTD but abolished LTP induction. The representative averaged traces of evoked EPSCs from different time points of control and AP-5 block are presented above the graph.