Figure 6.

Relieving effects of systemically administered clopidogrel in rats with tactile allodynia. Seven day postoperative rats showing strong tactile allodynia were subjected to verification of the analgesic effect induced by clopidgrel. Systemically administered clopidogrel (1, 10, and 25 mg/kg; n = 4, 5, and 6), but not vehicle (n = 3), also showed an analgesic effect in rats with tactile allodynia 7 d after peripheral nerve injury. Each data point represents the mean ± SEM of PWT (^$,#,*p < 0.05; 1, 10, and 25 mg/kg-treated groups vs vehicle group by multiple comparison by Tukey's test after a repeated-measure two-way ANOVA).