Figure 1.

The mitochondrial complex I inhibitor rotenone reduces the corticostriatal field potential and produces an irreversible membrane depolarization of striatal spiny neurons. A, Time course of the mean field potential amplitude measured in the presence of rotenone 0.1, 0.3, and 1 μm bath applied for 35 min. The traces represent a field potential recorded in control condition and at 20 and 30 min after the application of 1 μm rotenone. B, Representative trace showing the membrane depolarization of a spiny neuron in the presence of 1 μm rotenone and time course of the mean membrane potential amplitude of spiny neurons recorded in control condition and in the presence of 1 μm rotenone. C, Time course of the mean field potential amplitude recorded in the presence of 1, 30, and 100 μm rotenone, applied for 35 min in CA1 hippocampal slices. The traces represent a field potential recorded in control condition and at 20 and 30 min after the application of 100 μm rotenone. In Figures 1–9, the number of experiments represented in the graphs are indicated in text.