Figure 7.

The antiepileptic drug carbamazepine reduces in a dose-dependent manner the rotenone-induced reduction of the field potential amplitude. A, The rotenone-mediated reduction of the field potential amplitude was significantly reduced by the antiepileptic drug CBZ (30 μm), whereas LTG (10 μm), TPM (100 μm), and VPA (300 μm) did not exert any significant neuroprotection. B, Example traces of corticostriatal field potentials recorded in control condition and at different times from the onset of the application of rotenone alone (top traces) and in the presence of rotenone plus 30 μm CBZ (bottom traces). C, Dose–response curve of the effect of CBZ on the field potential amplitude measured after 60 min from the onset of the application of 1 μm rotenone.