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. 2019 Jul 25;10:514. doi: 10.3389/fpsyt.2019.00514

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Copyright © 2019 Camchong, Collins, Becker, Lim and Luciana

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Main effect of group of dorsal anterior cingulate cortex (ACC) resting-state functional connectivity (rsFC) identified by a 2 × 2 mixed-model (group × time) analysis controlling for alcohol and nicotine. (A) LEFT: Axial Montreal Neurological Institute (MNI) brain slice (z = 11) illustrating clusters that showed a significant main effect of group in rsFC between the dorsal ACC seed and (i) right medial frontal gyrus (MFG; Brodmann area 10; 276 voxels) and (ii) left MFG (Brodmann area 10; 293 voxels). (B) RIGHT: Bar graphs representing mean (error bars: +/− 1 standard error) illustrating significant main effects characterized by lower rsFC between dorsal ACC and (i) right middle frontal gyrus (MFG) (F = 9.621, p = 0.004) and (ii) left MFG (F = 11.278, p = 0.002) in individuals with cannabis use disorder (CUD) than healthy controls (HC) across time.