Table 4.

Significant group × time interaction. Montreal Neurological Institute (MNI) coordinates of clusters (center of mass) in which resting functional connectivity (rsFC) of caudal anterior cingulate cortex (ACC) showed a significant (per-voxel p = .001, cluster p = 0.025, two-tailed p = 0.0 5) Group (non-treatment-seeking individuals with cannabis use disorder vs. healthy controls) by time (Time 1 vs. 2) interaction ( Figure 1 ). No other significant interactions were found for other regions of interest. F and significance (Sig) p-values show analyses of covariance (ANCOVA) results controlling for the effects of differences in the sum of percent of variance accounted for by noise.

RsFC between Caudal ACC and:	Hemisphere	Brodmann area	x, y, z	F	Sig (p-value)	Cluster Size (# voxels)
Precentral gyrus	Right	6	30, −3, 50	14.09	.001	471
Inferior parietal lobule and precuneus	Right	7	40, −42, 48	12.46	.001	1,900