Table 5.
Significant main effect of group. Montreal Neurological Institute (MNI) coordinates of clusters (center of mass) in which resting functional connectivity (rsFC) of regions of interest (ROIs) showed a significant (per-voxel p = .001, cluster p = 0.025) main effect of group (non-treatment-seeking individuals with cannabis use disorder vs. healthy controls). No significant main effects of group were found for other regions of interest. F and significance (Sig) p-values show ANCOVA results controlling for the effects of differences in the sum of percent of variance accounted for by noise.
ROI | rsFC with: | Hemis-phere | Brod- mann area |
x, y, z | F | Sig (p-value) | Cluster size (# voxels) |
---|---|---|---|---|---|---|---|
Caudal anterior cingulate cortex (ACC) | Medial dorsal nucleus of the thalamus | Bilateral | — | 1, −18, 5 | 16.27 | .00023 | 1,940 |
Dorsal and rostral ACC and superior frontal gyrus (SFG) | Bilateral ACC, left SFG | 9, 10, 32 | −1, 39, 16 | 14.40 | .00048 | 6,877 | |
Medial frontal gyrus | Left | 10 | −30, 54, 16 | 14.13 | .00053 | 684 | |
Dorsal ACC | Medial frontal gyrus and superior frontal gyrus | Left Right |
10 10 |
−29, 59, 11 26, 61, 14 |
14.17 11.57 |
.00052 .00151 |
293 276 |