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. 2019 Jul 25;10:514. doi: 10.3389/fpsyt.2019.00514

Table 5.

Significant main effect of group. Montreal Neurological Institute (MNI) coordinates of clusters (center of mass) in which resting functional connectivity (rsFC) of regions of interest (ROIs) showed a significant (per-voxel p = .001, cluster p = 0.025) main effect of group (non-treatment-seeking individuals with cannabis use disorder vs. healthy controls). No significant main effects of group were found for other regions of interest. F and significance (Sig) p-values show ANCOVA results controlling for the effects of differences in the sum of percent of variance accounted for by noise.

ROI rsFC with: Hemis-phere Brod-
mann area
x, y, z F Sig (p-value) Cluster size (# voxels)
Caudal anterior cingulate cortex (ACC) Medial dorsal nucleus of the thalamus Bilateral 1, −18, 5 16.27 .00023 1,940
Dorsal and rostral ACC and superior frontal gyrus (SFG) Bilateral ACC, left SFG 9, 10, 32 −1, 39, 16 14.40 .00048 6,877
Medial frontal gyrus Left 10 −30, 54, 16 14.13 .00053 684
Dorsal ACC Medial frontal gyrus and superior frontal gyrus Left
Right
10
10
−29, 59, 11
26, 61, 14
14.17
11.57
.00052
.00151
293
276