Figure 8.

The lentiGFP/TLR2 treatment in the bone marrow rescues spatial and contextual memory in 6-month-old APP–TLR2 mice. The mean of trials to reach the criterion during the reversal phase in the T-water maze indicates that lentiGFP/TLR2-treated mice required significantly fewer trials to learn the task than APP–TLR2 transgenic animals that were treated with the control lentiGFP virus (a). It is of great interest to note that lentiGFP/TLR2-treated APP–TLR2 transgenic animals performed comparably with wild-type mice. **p < 0.01, *** p < 0.001 (one-way ANOVA; APP–TLR2 reproduced from Fig. 2, n = 9; lentiGFP, n = 11; lentiGFP/TLR2, n = 14). The lentiGFP/TLR2-treated animals also showed a higher step-through latency to enter the dark compartment during the passive avoidance task compared with controls (b). *p < 0.05 (one-way ANOVA; APP–TLR2 reproduced from Fig. 3, n = 9; lentiGFP, n = 5; lentiGFP/TLR2, n = 7). APP–TLR2 mice received the different lentivirus preparations at 2.5–3 months of age and were tested 3 months later. For details, see Materials and Methods. Error bars indicate SEM.