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. 2019 Jul 25;10:1718. doi: 10.3389/fimmu.2019.01718

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Copyright © 2019 Chen, Tay, Brzostek, Gascoigne and Rybakin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PHA-767491 inhibition can be reproduced by other Cdc7 and Cdk9 inhibitors. PHA-767491, XL-413, LDC067, and SNS-032 were used to examine the effects of Cdc7 and Cdk9 inhibition in (A) lymphocytes stimulated for 3 h, (B) lymphocytes stimulated for 17 h, or (C) thymocytes stimulated for 17 h. The percentages of the positive population of each sample are shown in the plots. Data shown is representative of at least three separate experiments. (D) The averaged results of the experiments from (A–C) are represented as mean ± SEM. Statistical significance was determined by unpaired two-sided Student's t-test (ns, non-significant; *p < 0.05; **p < 0.01; ***p < 0.001).