Figure 4.
Effect of pioglitazone on the cholinergic innervation. A, The significant decrease in the number of ChAT fibers detected in APP mice compared with wild-type littermates (★p < 0.05, Student's t test) was improved by pioglitazone (pio), although not significantly, but not by NAC (data not shown). Data are from one representative experiment of three independent ones. B, Pioglitazone also slightly attenuated Aβ plaque-associated neurotoxicity as a smaller percentage of Aβ1–42-positive plaques (gray) were surrounded by dystrophic ChAT terminals (brown) (n = 3–5 mice/group). Scale bar, 10 μm. Error bars represent SEM.