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. 2008 Jul 2;28(27):6818–6825. doi: 10.1523/JNEUROSCI.1564-08.2008

Figure 3.

Figure 3.

Somatic light responses from 129/Sv and CNGA3-deficient retinas. Light stimuli are the same as in Figure 2. A, 129/Sv wild-type horizontal cell somata showed much more consistent light response properties than somata from C57BL/6 mice. B, Somatic recordings from CNGA3-deficient retinas were easily distinguishable from the wild type. The square time course of the stimulus, visible in wild-type responses, is absent in responses from CNGA3-deficient retinas. A, B, Calibration: 5 mV, 250 ms. C, Normalized intensity–response profiles for 129/Sv wild-type (n = 8) and CNGA3-deficient horizontal cell somata (n = 5). Error bars indicate mean ± SE. Horizontal cell somata from CNGA3-deficient retinas responded to much lower light intensities than did 129/Sv wild-type horizontal cells (p < 0.05). This huge shift in the intensity–response profile reflects the pure rod input to horizontal cells in the CNGA3-deficient retina.