Figure 5.

Synaptically driven b-APs trigger dendritic BDNF secretion through membrane depolarization. a, Synaptically induced b-APs, occurring when neurons were held at −52 ± 1 mV, produced a dendritic BDNF-GFP secretion (n = 5); the arrow indicates the arrival of the first AP. Left, Representative trace. b, BDNF-GFP secretion did not occur when APs were prevented by QX314 in the recording pipette (n = 9). Left, Representative trace. c, Membrane depolarization to −40 mV, with QX314 in the pipette, produced a BDNF-GFP secretion even in the absence of APs (n = 6). Left, Representative trace. Rel., Relative.