Figure 1.

ThioS labels neurofibrillary tangles in vivo. Topical application of 0.025% ThioS to the cortex of rTg4510 mice was used to observe neurofibrillary tangles. a, b, Low-magnification micrographs show that NFTs are prevalent throughout the cortex of 6-month-old (a) and 9-month-old (b) mice. c–e, At high resolution, most of these lesions appear blue-green and fibrillar although occasionally less fibrillar lesions are observed which are more blue in color (arrow). ThioS positive neurons were not observed in control animals (data not shown). Scale bars: a, b, 20 μm; c–e, 10 μm.