Table 3.

fMRI signal increases and decreases during the observation of both painful and disgusting stimuli

	cluster	Voxel level		MNI coordinates (mm)			Talairach coordinates (mm)
	k	z	p	x	y	z	x	y	z
Brain areas displaying fMRI signal increases during the observation of both painful and disgusting stimuli [(P − N) + (D − N)]
L medial superior frontal gyrus (BA 9)	92	4.00	< 0.001	−16	40	32	−16	40	27
		3.70	< 0.001	−16	42	42	−16	43	37
L medial prefrontal cortex (BA 11)/pACC (BA 32)	39	3.99	< 0.001	−4	32	−16	−4	30	−15
pACC (BA 24/32)	109	4.82	< 0.001	−2	26	−2	−2	25	−3
		3.93	< 0.001	8	34	−2	8	33	−3
Mid-cingulate cortex (BA 24)	88	4.22	< 0.001	0	2	36	0	4	33
		3.74	< 0.001	0	−10	40	0	−8	37
L posterior cingulate cortex (BA 23)	27	3.46	< 0.001	−6	−62	14	−6	−59	16
L insular cortex/ superior temporal gyrus/claustrum (BA 13/21)	86	5.29	< 0.001	−38	−4	−14	−38	−4	−12
		3.99	< 0.001	−40	−14	−8	−40	−14	−6
		3.79	< 0.001	−38	−18	2	−38	−17	3
R parietal operculum (BA 43)	72	3.95	< 0.001	56	−16	20	55	−15	19
Brain areas displaying fMRI signal decreases during the observation of both painful and disgusting stimuli [(N − P) + (N − D)]
R middle frontal gyrus (BA 10, 11)	165	4.42	< 0.001	38	60	−2	38	58	−5
		3.78	< 0.001	28	62	−8	28	60	−10
		3.55	< 0.001	36	62	8	36	60	4
R middle frontal gyrus (BA 10, 46)	196	4.85	< 0.001	46	44	22	46	44	18
		3.66	< 0.001	38	46	22	38	46	18
R middle frontal gyrus (BA 11, 10, 47)	48	4.03	< 0.001	44	50	−12	44	48	−12
		3.68	< 0.001	46	54	−2	46	52	−4
R superior frontal gyrus (BA 6, 8)	101	4.75	< 0.001	22	22	56	22	24	50
		3.86	< 0.001	22	14	64	22	17	58
		3.57	< 0.001	28	30	56	28	32	50
R middle frontal gyrus (BA 6)	39	4.41	< 0.001	32	14	60	32	16	54
R inferior parietal lobule (BA 40)/ supramarginal gyrus	424	5.15	< 0.001	52	−48	44	51	−44	43
		3.72	< 0.001	58	−56	30	57	−53	30
		3.50	< 0.001	52	−60	38	51	−56	38

L, Left; R, right; BA, Brodmann area.