Figure 2.
Effects of Aβ1–42 globulomer on different types of synaptic currents in cultured hippocampal neurons. Black bars, Effect of Aβ1–42 globulomer (glob); white bars, washout for at least 10 min (wash). A, Reduction of event frequency as percentage of previously recorded control currents (100%). B, Effects of Aβ1–42 globulomer on median amplitude of the respective currents. sPSCs, Spontaneously occurring pharmacologically naive PSCs; mPSCs, pharmacologically naive mPSCs recorded in the presence of TTX.