Figure 7.
Steady-state activation and inactivation parameters of P/Q currents. Curves are reconstructed from the averaged parameters Vh, Vc, and g max, respectively (see Materials and Methods). A, Current–voltage relationship before globulomer (squares) and during Aβ1–42 (triangles). A reduction of the current amplitudes over the entire voltage range, where the current could be activated, was observed after application of the globulomer. B, C, No difference in steady-state activation (B) and inactivation (C) curves for P/Q channel-mediated barium currents in the absence and presence of Aβ1–42 globulomer. D, A significant decrease in maximal conductance (g max) of the P/Q channels was induced by Aβ1–42 globulomer (glob), whereas other activation parameters (Vh, Vc) remained unchanged. Insets represent the command voltage protocols.