Figure 8.
Pharmacological modulation of the effect of Aβ1–42 globulomer by agents interacting with P/Q-type calcium channels. A, Left bars, ω-Agatoxin reduces the frequency of spontaneous synaptic currents (white bar). Additional application of the globulomer (glob) does not exert an additional effect (black bar). Right bars, The reduction in frequency by Aβ1–42 globulomer can partially be recovered by application of the P/Q current enhancer roscovitine. B, Effects on median amplitude. Values are given relative to data in control solution.