Figure 5.

Summary of L-LTP in stimulated S1 synapse after strong stimulation in S0 synapse. Mean fEPSP slopes 180 min after weak tetanus were presented. Single tetanus was paired with four trains of 100 Hz tetanus in S0 in WT, WT+GRGDSP, WT+cytochalasin D, WT+nitrendipine, and WT+anisomycin. Using KO mice coadministered with rmNP, single tetanus was paired with four trains of 100 Hz tetanus in S0 (KO, KO+rmNP, KO+rmNP+GRGDSP, KO+rmNP+cytochalasin D, KO+rmNP+nitrendipine, and KO+rmNP+anisomycin). KO mouse slices impaired single tetanus-induced synaptic association, which was reversed with rmNP administration. Late-association LTP was impaired by bath application of GRGDSP, cytochalasin D, and nitrendipine but not by bath application of anisomycin. Asterisks indicate statistical significance (*p < 0.05). Error bars indicate SEM.