Figure 7.

NMDARs as coincidence detectors. Model of the influence of the NR2A and NR2B subunits on the NMDAR as a coincidence detector. NR2A confers a short, NR2B a long integration window for detection of coincident inputs, whereas control cells with signaling through both receptors have an intermediate window. We suggest that the ability of control cells to detect a wider range of correlated inputs that carry useful information for the neuron is critical for the establishment of normal dendritic arbor structure. The detection of inputs is marked by X.