Figure 5.

LPS induces a delayed increase in the recruitment of perivascular macrophages. a–d, Different types of bone marrow-derived cells stained for GFP by immunohistochemistry in brain sections from chimeric mice. Scale bar: a–d, 10 μm. e, Stereological analysis revealed increased numbers of adherent leukocytes and perivascular macrophages expressing GFP in the cerebral cortex of mice killed 1 or 3 d after intraperitoneal LPS injection (n = 9 per group). *Two-way ANOVA: treatment effect, p < 0.0001; time effect, p > 0.05; interaction, p > 0.05. **Two-way ANOVA: treatment effect, p = 0.014; time effect, p < 0.0001; interaction, p = 0.0037. Error bars indicate SEM.