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. 2008 Apr 2;28(14):3595–3603. doi: 10.1523/JNEUROSCI.5536-07.2008

Figure 4.

Figure 4.

Overexpression of RPM-1 causes short PLM axon extension. The PLM axons were visualized with zdIs5 [mec-4::gfp]. RPM-1 overexpression was obtained using a transgenic line, which carried the integrated rpm-1::GFP transgene (juIs58). A, In wild-type animals, PLM axons stop their anterior extension near the vulva (arrow). B, In juIs58 worms, PLM displays short extension (arrowhead). C, Quantification of the PLM short extension in different mutant backgrounds. The PLM is also shorter in sax-3 and unc-5 mutants, suggesting that RPM-1 might negatively regulate SAX-3 and UNC-5 activity to affect PLM extension. Asterisks indicate statistically significant difference (*p < 0.05; **p < 0.005). Anterior is left and dorsal is up; stars indicate the position of vulva. Error bars represent SEs of proportions. Scale bars, 20 μm.