Figure 1.

Quantitative changes in sleep characteristics in adult mice that had received early-life treatment. WT mice had been treated with saline (WT) or the SSRI escitalopram (WTneoSSRI). Mice with a genetic deletion of the serotonin transporter had been treated with saline (KO). A, Examples of hypnograms from mice from three different groups. B, REMS total duration (left), number of episodes (center), and average latency from sleep onset (right). C, NREMS total duration (left), number (center), and mean duration (right) of episodes for eight WT, nine WTneoSSRI, and seven KO mice. Light phase, 7:00 A.M. to 7:00 P.M.; dark phase, 7:00 P.M. to 7:00 A.M. Values plotted are mean ± SEM *p < 0.05; **p < 0.01; ***p < 0.001, significant difference between groups.