Figure 4.

Effect of TsA on cocaine-induced locomotor activity. a, Two groups of rats were given intravenous injections of TsA (0.3 mg/kg) or vehicle (10% DMSO) daily for 4 d. Thirty minutes after the fourth injection, both groups of rats were treated intravenously with 1 mg/kg cocaine (time 0). Locomotor activity was expressed over 15 min periods. b, The intravenous injection protocol (0.3 mg/kg TsA followed 30 min later by 1 mg/kg cocaine) was repeated daily for 5 d. On day 11, only cocaine was administered. Locomotor activity was expressed over 10 min periods. Each point represents the mean ± SEM (n = 6, vehicle-treated group; n = 8, TsA-treated group) of crossings. ^# p < 0.05; ** or ^## p < 0.01 and ***p < 0.001. *Significance when comparing each value to that obtained at time 0 in a or at day 1 in b; ^#significance when comparing TsA group to vehicle group (ANOVA followed by Student–Newman–Keuls multiple comparisons test).