Figure 2.
CD11b+ cells are required for recovery of sciatic nerve functions after injury. a, Recovery of locomotor functions from a sciatic nerve lesion, as determined by the sciatic function index (SFI), is severely compromised in GCV-treated CD11b-TKmt-30 (TK) transgenic mice compared with control groups, with large deficits persisting even at 49 d after lesion (n = 12 per group). b, When minipumps were removed at 7 d after lesion in TK mice, transgenic animals recovered after 6–7 weeks (n = 12 per group). Error bars indicate SEM. c–e, Representative examples of the typical posture adopted by saline-treated WT (c) and GCV-treated TK (d, e) mice at 35 (d) and 49 (c, e) days after lesion of their left sciatic nerve. ***p < 0.001 and **p < 0.01 compared with respective control groups.