Figure 3.
Responses to cytoplasmic [Ca2+] of RyR channels from control (open symbols) and ischemic (filled symbols) brains. Fractional open times (Po*) of low (circles), moderate (triangles), and high (diamonds) activity channels are depicted as a function of free [Ca2+]. Symbols and error bars depict mean and SE values, respectively. Continuous lines represent the best nonlinear fits to the equation in Materials and Methods of all individual experimental data values obtained for control channels with low, moderate, or high activity. All parameter values obtained are displayed in Table 1.