Skip to main content
. 2008 Jan 2;28(1):208–216. doi: 10.1523/JNEUROSCI.3674-07.2008

Figure 5.

Figure 5.

MMP2/9 blockade inhibits androgen-induced angiogenesis and neuronal addition. A, The experimental timeline for assessing the effects of SB-3CT-mediated MMP inhibition on testosterone-induced angiogenesis and neuronal addition. B, BrdU+/laminin+ newly generated endothelial cells, in an adult female HVC microvasculature 9 d after testosterone administration (11 d after vehicle injection), with daily BrdU administration from throughout. C, Confocal validation, with orthogonal side views, of laminin immunoreactivity (red) by the BrdU+ (green) cells. D, The incidence of newly generated endothelial cells (BrdU+/laminin+), expressed as a percentage of all laminin+/DAPI+ endothelial cells within the border of HVC. E, F, Examples of scored BrdU+/Hu+ cells. Confocal validation of the double labeling of BrdU+ (green)/Hu+ (red). G, The incidence of newly recruited BrdU+/Hu+ neurons, expressed as a percentage of all Hu+ neurons in HVC. Scale bars: B, E, 50 μm; C, F, 10 μm. ***p < 0.001 by ANOVA with Bonferroni t tests. T, Testosterone; NS, null (empty) SILASTIC.