Figure 2.

Exploratory behavior in the novel open field and the elevated plus maze of PN-antidepressant- and PN-vehicle-treated mice. A, Total ambulatory time in the novel open field (OF). B, Total vertical activity in the novel open field. C, Total arm entries in the elevated plus maze (EPM). VEH, PN-vehicle; FLX, PN-fluoxetine; CMI, PN-clomipramine; CTM, PN-citalopram; DMI, PN-desipramine. Mean ± SEM values are shown (n = 40–65 per group). *p < 0.05; **p < 0.01; ***p < 0.001 compared with PN-vehicle.