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Sensory neuron development in Δ446/Δ446 mice. A, Schematics for full-length Runx1 protein and the truncated Δ446 protein. The wild-type Runx1 protein (“Runx1”) contains the DNA-binding motif “runt,” the activation domain “AD,” and the C-terminal repression domain “RD.” Δ446 is a truncated Runx1 protein that lacks the RD. B, Double staining of IB4 (red) and full-length or truncated Runx1 protein (green) on sections through T12 thoracic DRG of wild-type and Δ446/Δ446 mice.
