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. 2008 Mar 5;28(10):2447–2458. doi: 10.1523/JNEUROSCI.1926-07.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/282447-12$15.00/0

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Figure 6. — Depression of preBötC rhythms by block of NK1 receptors. A, Rhythm in 3 mm K⁺ with a eupnea–sigh burst pattern in a m-preBötC[350/−0.69]W-P1 slice was abolished 12 min after the start of bath application of the NK1 receptor antagonist GR82334. Recovery of the rhythm was incomplete within 18 min after the start of the washout of GR82334. B, Statistical analysis of the effects of the NK1 antagonist (2.5 μm) on nine m-preBötC[500/−0.75]W-P1/4 slices (gray bars) and four m-preBötC[350/−0.70]W-P1/2 slices (black bars). Note that the block was more pronounced in the thinner slices. C, In 3 mm K⁺, a m-preBötC[500/−0.68]W-P0 slice generated rhythm with a eupnea–sigh burst pattern. D, After onset of in vitro apnea in the slice of C, bath application of the NK1 receptor agonist GR73632 restored a very similar eupnea–sigh burst pattern. GR82334 abolished the agonist-evoked rhythm within 4 min, whereas the rhythm was fully restored 10 min after washout of the NK1 antagonist. E, Statistical analysis of the depressing effects of GR82334 (2.5 μm) on the rhythms evoked by GR73632 (5 nm) in a group consisting of two m-preBötC[350/−0.70]W-P0 and two m-preBötC[500/−0.74]W-P2 slices. In B and E, digits in bars indicate the number of slices.